Farmacologia e Tossicologia Veterinaria

VET/07 - FARMACOLOGIA E TOSSICOLOGIA VETERINARIA  (EX: V33A - FARMACOLOGIA E TOSSICOLOGIA VETERINARIA)
Il settore raggruppa discipline e tematiche di ricerca che riguardano lo studio dei farmaci di interesse veterinario e in particolare ne considera il meccanismo di azione e farmacodinamia, farmacocinetica, le indicazioni terapeutiche, modalità e forme di somministrazione nelle diverse specie animali, farmacovigilanza e farmacosorveglianza nonché - limitatamente alle specie da reddito - le norme legislative nazionali ed europee finalizzate alla tutela della salute pubblica e dell'ambiente. È altresì specifico interesse del settore lo studio delle fonti, delle proprietà dinamiche e cinetiche, dei rilievi sintomatologici e autoptici propri di sostanze tossiche di origine diversa attinenti al mondo agricolo e veterinario per la definizione di provvedimenti antidotali e conservativi, della salvaguardia del benessere animale e dell'ambiente, dell’influenza da esse esplicata sulle produzioni zootecniche e della possibilità di utilizzo degli animali come indicatori biologici di stati contaminativi ambientali. L'attività del settore si completa con lo studio delle principali metodologie farmaco-tossicologiche di carattere biotecnologico suscettibili di utilizzazione in campo veterinario.
Docenti:
 Professore di I Fascia

Prof. Intorre Luigi

 

Professore di II Fascia

Prof. Giorgi Mario

 

Ricercatori Dott.ssa. Meucci Valentina

 

Prof. Intorre Luigi

Linee di Ricerca

 

Resistenza ai farmaci antibiotici con l’utilizzo sia di tecniche colturali (diluizione, microdiluizione, disco-diffusione) che molecolari (PCR) su isolati di patogeni e commensali con particolare attenzione agli stafilococchi isolati dal cane ed ai meccanismi di resistenza ai fluorochinoloni e la meticillino-resistenza.

Farmacocinetica, deplezione dei residui e sicurezza d’uso di farmaci veterinari e contaminanti inclusi studi di cinetica plasmatica e residuale sia negli animali da reddito (con particolare interesse verso le specie minori e le specie ittiche) sia negli animali d’affezione (cane), incluso lo sviluppo di metodiche analitiche classiche (HPLC) ed innovative (sensori elettrochimici) e la valutazione della sicurezza nella specie bersaglio nelle condizioni d’uso proposte.

Valutazione della tossicità di farmaci, micotossine e contaminanti inclusi studi di valutazione della tossicità di xenobiotici su vari modelli sperimentali, con particolare riferimento a specie acquatiche (vertebrati ed invertebrati), anche mediante l’identificazione di biomarker di esposizione e di tossicità.

Farmacologia comparata delle funzioni gastro-intestinali, inclusi lo studio dei meccanismi di controllo e modulazione delle secrezioni esocrine ed endocrine e della motilità del tratto gastro-intestinale del cane con particolare riferimento ai meccanismi di controllo colinergico, adrenergico, istaminergico e peptidergico.

 


Dott. Giorgi Mario

Address

Lng San Giovanni al Gatano, 9

56122 Pisa, Italy

Mobile: 345 5294222

Place of work

Pharmacology and Toxicology Division

Department of Veterinary Sciences

University of Pisa

Via Livornese (lato monte) 1, San Piero a Grado - 56010

Pisa, Italy

Phone: +39 (0)50 2210154; fax: +39 (0)50 2210182

E-mail Questo indirizzo email è protetto dagli spambots. E' necessario abilitare JavaScript per vederlo.

Personal information

Date of Birth: May 23rd, 1969

Place of Birth: Cascina, Pisa

Registry office: bachelorhood

Military service: performed

Education

High School, Scientific Lyceum

Pharmacological experimental dissertation: [In vivo study of antihypertensive activity of a series of 1,8-naftyridinic 2,4 substituted. In vitro evaluation of the possible mechanism of action.]

University of Pisa, Faculty of Pharmacy: Degree in Pharmaceuticals Chemistry and Technologies (C.T.F.) achieved on April 17th, 1997

Professional qualification achieved on December 12nd, 1997

Post-graduate course (4 years specialisation school) in Applied Pharmacology, Faculty of Human Medicine of University of Pisa, Italy

Professional experiences

Under-graduate student in the laboratory of Pharmacology, Faculty of Pharmacy, University of Pisa

Post graduate student in the Pharmacology and Toxicology Section, Department of Veterinary Clinics, University of Pisa

Post-graduate student in the Mutagenesis and Ecotoxicity Division and in the Toxicological Biochemistry of the Proteins Division, Institute of Mutagenesis and Differentiation, National Research Council (C.N.R), Pisa

Post-graduate student in the Unité de Toxicologie et Métabolisme Comparés des Xénobiotiques de l’Ecole Nationale Vétérinaire in Lyon

Post-graduate student in the Toxicological Forensic Section of the Department of Public Health, University of Pisa

Since 1st June 2001, assistant professor in Veterinary Pharmacology and Toxicology

Since 2004 aggregate professor in Veterinary Medicine and Pharmacy Faculties

Qualified as both associate and full professor on February 2014

Scientific experiences

Main research fields:

Development and validation of new analytical methods for xenobiotics’ detection in biological matrices

Pharmacokinetics/Pharmacodynamic studies in different animal species

Effects of xenobiotics on the activity of the monooxygenase system

Toxicological analyses in forensic medicine

Translational studies (animals to humans)

Research periods at foreign institutions

2007, 2008, 2009, 2013 Veterinary school, Lublin University (Poland)

2009, 2013 Veterinary College, CNU (South Korea)

2009, 2011 Koret Veterinary School, Hebrew University of Jerusalem (Israel)

2010 School of Veterinary Medicine, University of Queensland, Gatton, Brisbane (Australia)

2011 School of Veterinary Medicine, University of Queensland, Gatton, Brisbane (Australia)

2012 School of Veterinary Medicine, College of Agriculture and Animal Husbandry, Quinghai University, Xining (China)

Foreign language

English, (French)

Society affiliations

Member of International Society for Animal Clinical Biochemistry (ISACB)

Member of S.I.S Vet (Italian Veterinary Science Society)

Member of SITOX (Italian Society of Toxicology)

Member of SIF (Italian Society of Pharmacology)

Member of the Health & Antidoping Committee of CONI (National Olympic Italian Committee)

Referee for:

Diseases of Aquatic Organism; Veterinary Journal; Archives of Medical Science; Iranian Journal of Veterinary Research; Health; Asian Journal of Pharmaceutics; Natural Product Communications; Journal of Pharmaceutical and Biomedical Analysis; Journal of Food Composition and Analysis; Veterinary Science Development; Neurochemistry International; Journal of Experimental Pharmacology; Biochemical Science; Drugs and Therapy Studies; Central European Journal of Chemistry, Journal of Chromatography & Separation Techniques; Journal of Gastroenterology and Hepatology, Walailak Journal of Science and Technology, Bioanalysis, The Chemical Industry and Chemical Engineering Quarterly, Journal of Veterinary Medicine: Research and Reports, Toxicology Mechanisms and Methods, World Mycotoxin Journal, Journal of Equine Veterinary Sciences, Medycyna Weterynarjyna, Veterinary and Comparative Oncology, Molecular Pharmaceutics, BMC Veterinary Research, Journal of Analytical Toxicology, Journal of Analytical Science and Technology, Food and Chemical Toxicology, Systems Biology in Reproductive Medicine; Journal of Liquid Chromatography & Related Technologies (ISSN 1082-6076); African Journal of Pharmacy and Pharmacology (ISSN: 1996-0816); Journal of Chromatography A (ISSN: 0021-9673); Journal of Pharmacy and Pharmacology (ISSN: 2042-7158) Research in Veterinary Science (ISSN: 0034-5288); Arabian Journal of Chemistry (ISSN: 1878-5352); Drug Design, Development and Therapy (ISSN: 1177-8881); Bioanalysis (ISSN: 1757-6180); Molecules (1420-3049); The Journal of Veterinary Medical Science (ISSN: 0916-7250); Biomedical Journal (ISSN:

Editor in chief of:

Research Journal of Pharmacy and Pharmaceutical Science

Editorial board member of:

The Veterinary Journal (ISSN: 1090-0233); American Journal of Animal and Veterinary Sciences (ISSN: 1557-4555); Medycyna Weterynaryjna (ISSN: 0025-8628), Clinical & Experimental Pharmacology (ISSN: 2161-1459), Journal of Comparative Clinical Pathology Research (ISSN: 2252 - 0422); Asian Journal of Pharmacology and Toxicology (ISSN: 2347-3886); Publication of Medical and Pharmaceutical Sciences; 3I: Intellect, Idea, Innovation (ISSN: 2226-6070); PENCIL Publication of Medical and Pharmaceutical Sciences; Journal of Veterinary Science and Research (Jacobs Publisher).

Reviewer of domestic and international research projects:

MIUR; University of Teramo; National Centre of Science and Technology Evaluation (Republic of Kazakhstan); National Science Centre (Poland); University of California, Davis USA, academic career reviewer.

Teaching experiences

Since 2004 holder of several courses in Pharmacology and Toxicology at the Faculties of Veterinary Medicine and Pharmacy of the University of Pisa. For further information, please see my personal web page. http://unimap.unipi.it/cercapersone/dettaglio.php?ri=198&template=dettaglio.tpl

Briefely:

2004-2005      Pharmacology & Toxicology in food producing animals (VM Faculty)

2005-2006      Environmental Toxicology (VM Faculty)

                       Pharmacology, Pharmacotherapy and Toxicology (Pharmacy Faculty)

                       Residues and drugs analysis in food (Pharmacy Faculty)

2006-2007      Pharmacology, Pharmacotherapy and Toxicology (Pharmacy Faculty)

                       Residues and drugs analysis in food (Pharmacy Faculty)

                        Safety of the wild environment and pollution control (VM Faculty)

2007-2008      Pharmacology, Pharmacotherapy and Toxicology (Pharmacy Faculty)

                       Residues and drugs analysis in food (Pharmacy Faculty)

                       Environmental Toxicology (VM Faculty)

                       Toxicology (Animal Health Specialisation School, VM Faculty)

2008-2009      Pharmacology, Pharmacotherapy and Toxicology (Pharmacy Faculty)

                       Residues and drugs analysis in food (Pharmacy Faculty)

                       Environmental Toxicology (VM Faculty)

                       Toxicology (Animal Health Specialisation School, VM Faculty)

                       Pharmacology, Toxicology and Chemotherapy (some lectures, VM Faculty)

2009-2010      Pharmacology, Pharmacotherapy and Toxicology (Pharmacy Faculty)

                       Residues and drugs analysis in food (Pharmacy Faculty)

                       Pharmacology, Toxicology and Chemotherapy (some lectures, VM Faculty)

                       Toxicology (Animal Health Specialisation School, VM Faculty)

2010-2011      Pharmacology (Small Animal Specialisation School,VM Faculty)

Pharmacology (Master in Anesthesia and Analgesia)

2011-2012          Pharmacology (Master in Animal Behavior)

                       Pharmacology (Master in Chemotherapy)

                       Toxicology (Master in Food Science)

2012-2013      Veterinary Pharmacology (Veterinary School at Kostanay State University)

                       Toxicology (Animal Health Specialisation School, VM Faculty)

2013-2014      The Veterinary Dug (Animal Health Specialisation School, VM Faculty, Sassari)

2013-2014      Veterinary Pharmacology (Veterinary School at Kostanay State University)

Lectures abroad:

Veterinary School, Lublin University, Poland (2009-2010 visiting research investigator) (2011 Erasmus program)

Veterinary School, Seoul National University, Seoul, South Korea (2009, 2011)

National Veterinary Research and Quarantine Service, Seoul, South Korea (2009)

Veterinary School, Kostanay, Kazakhstan (2011, 2012, 2014)

Pharmacy School, Tehran Medical University, Tehran, Iran (2011)

School of Veterinary Medicine, College of Agriculture and Animal Husbandry, Quinghai University, Xining, China (2012)

Veterinary School, Kyonpook National University, Daegu, South Korea (2013)

Quarantine Inspection Agency (QIA), Anyon, Seoul, South Korea (2013)

School of Veterinary Medicine, Cardinal Herrera University (CEU), Valencia, Spain, 2013 (Erasmus program)

College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea (2013, 2014)

Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Turkey (2014) (Tubitak program)

International cooperation, collaborations and links

School of Veterinary Medicine, Chungnam National University, Daejeon (South Korea) (visiting professor)

Faculty of Agriculture, University of Life Sciences, Lublin (Poland) (visiting research investigator)

School of Veterinary Medicine Hebrew University of Jerusalem (Israel) (visiting research investigator)

School of Veterinary Medicine, Massey University, Palmestron North (New Zealand) (visiting professor)

School of Veterinary Medicine, University of Tehran (Iran) (visiting professor)

School of Veterinary Medicine, University of Queensland, Gatton, Brisbane (Australia) (visiting research investigator)

School of Veterinary Medicine, Kostanay State University, Kostanay, (Kazakhstan) (visiting professor with temporary duty as pharmacology Professor)

School of Veterinary Medicine, College of Agriculture and Animal Husbandry, Quinghai University, Xining, China (visiting professor)

School of Veterinary Medicine, Ross University, Basseterre (St Kitt and Nevis) (visiting professor)

Supervisor

Since 2001 supervisor of students (Pharmacy and Veterinary Medicine) for their experimental final studies (thesis). In 2008 supervisor of a Chinese professor (6 months), in 2011 of one Egyptian (4 months) and one Kazakhstani PhD (3 years) student, in 2012 and 2013 two PhD students from South Korea (one year), one PhD student from Egypt in 2013 (one year).